Connect with us

affilate software business

Tech

Israeli scientists find way to treat deadly pancreatic cancer in 14 days – Health & Science

Published

on


A new treatment developed by Tel Aviv University could induce the destruction of pancreatic cancer cells, eradicating the number of cancerous cells by up to 90% after two weeks of daily injections of a small molecule known as PJ34.Pancreatic cancer is one of the hardest cancers to treat. Most people who are diagnosed with the disease do not even live five years after being diagnosed.The study, led by Prof. Malka Cohen-Armon and her team at TAU’s Sackler Faculty of Medicine, in collaboration with Dr. Talia Golan’s team at the Cancer Research Center at Sheba Medical Center, was recently published in the journal Oncotarget.Prof. Malka Cohen-Armon and Dr. Talia Golan (Credit: Tel Aviv University)Specifically, the study found that PJ34, when injected intravenously, causes the self-destruction of human cancer cells during mitosis, the scientific term for cell division.The research was conducted with xenografts, transplantation of human pancreatic cancer into immunocompromised mice. A month after being injected with the molecule daily for 14 days, “there was a reduction of 90% of pancreatic cells in the tumor,” Cohen-Armon told The Jerusalem Post. “In one mouse, the tumor completely disappeared.”“This molecule causes an anomaly during mitosis of human cancer cells, provoking rapid cell death,” she said. “Thus, cell multiplication itself resulted in cell death in the treated cancer cells.”Moreover, she said, PJ34 appears to have no impact on healthy cells, thus “no adverse effects were observed.” The mice, she said, continued to grow and gain weight as usual.She added that she first published about the mechanism in 2017 when it was used to effectively treat triple-negative breast cancer implanted in xenografts. This type of breast cancer – which tests negative for estrogen receptors, progesterone receptors and excess HER2 protein – like pancreatic cancer, is very hard to treat and many women don’t live more than five years after being diagnosed.Though Cohen-Armon said the team did not specifically study whether or not the treatment could prolong the lifespan of a patient, one can assume such an effect could result if the cancerous cells are eliminated.How long will it take to move from mice trials to human trials?She estimates that would take “at least two years on the condition that we get enough funding.”First, she said, the group will test the treatment on pigs and then apply for permission from the FDA to administer humans with this molecule.“I am optimistic,” Cohen-Armon concluded.





Source

Continue Reading
Partners
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

Tech

As U.N. Climate Talks Go to Overtime, a Battle for the ‘Spirit’ of the Paris Pact

Published

on

By


MADRID — After two weeks of contentious negotiations, world leaders put in charge of averting a cluster of accelerating climate threats remained at loggerheads on Saturday about whether they could commit, just on paper, to raise voluntary climate targets next year.

The annual talks, which had been scheduled to end on Friday, were meant to hammer out the final details of the landmark 2015 Paris climate accord, and expectations initially ran high that they would yield a collective political call for raising climate targets.

That is vital for the future of millions. With greenhouse gas emissions on their current trajectory, average global temperatures are on pace to increase to levels where heat waves are very likely to intensify, storms are set to become more severe, and coastal cities are at risk of drowning, according to scientific consensus.

The delegates from nearly 200 countries who gathered in the Spanish capital were similarly stuck on two other issues that have vexed the Paris Agreement since its inception: working out rules for an international carbon trading system and providing money for the poor countries that suffer most from climate catastrophes.

The draft texts that emerged early Saturday immediately set off furious criticism from inside and outside the plenary room. By midday, delegates were waiting for new drafts and there was no telling when the sessions would wrap up, with or without an agreement.

“Adopting this would be a betrayal of all the people around the world suffering from climate impacts and those who are calling for action,” said Jennifer Morgan, the executive director of Greenpeace International.

Diplomats and advocates at the deliberations repeatedly cited opposition from large economies that are run by leaders suspicious of international cooperation — including Australia, Brazil and the United States, the only country in the world that is pulling out of the Paris accord.

The United States delegation was among those that objected to the notion that the conference document should signal the need to enhance climate targets next year, saying it did not support “expansive additional language on gaps and needs.”

And while the divide between rich and poor countries loomed over these talks, as they often do in climate negotiations, the battle lines were far more muddled this time. Many countries from the global South, like Fiji and Colombia, insisted on higher ambitions by 2020, while India was among those that resisted such a deadline.

“The spirit and the objectives of the Paris Agreement are being eroded clause by clause, discussion by discussion,” Simon Stiell, the environment minister of Grenada, said as the negotiations entered the final stretch.

The lackluster diplomatic results stood in sharp contrast to the climate risks roiling the world beyond the conference center, with Arctic temperatures at near record highs this year, smoke from wildfires choking Sydney, Australia, and millions of young people pouring out into the streets for much of this year.





Source

Continue Reading

Tech

HiTech Group Australia (ASX:HIT) Trading Up 0.8%

Published

on

By


HiTech Group Australia Limited (ASX:HIT)’s stock price traded up 0.8% during trading on Thursday . The stock traded as high as A$1.19 ($0.84) and last traded at A$1.19 ($0.84), 4,900 shares changed hands during mid-day trading. The stock had previously closed at A$1.18 ($0.84).

The stock has a market cap of $45.28 million and a price-to-earnings ratio of 15.66. The business’s 50 day moving average is A$1.12 and its 200 day moving average is A$1.07.

About HiTech Group Australia (ASX:HIT)

HiTech Group Australia Limited provides recruitment services for permanent and contract staff to the information and communications technology (ICT) industry in public and private sectors in Australia. Its permanent recruitment services comprise the search and selection of candidates for full time employment; and ICT contracting services include the provision of ICT professionals for temporary and other non-permanent staffing needs of clients for specific projects in system development, infrastructure support and cloud integration, operation, and other skill sets.

Featured Story: Are sell-side analysts objective?

Receive News & Ratings for HiTech Group Australia Daily – Enter your email address below to receive a concise daily summary of the latest news and analysts’ ratings for HiTech Group Australia and related companies with MarketBeat.com’s FREE daily email newsletter.



Source

Continue Reading

Tech

New NASA mission will allow scientists to track rising seas from space

Published

on

By


Scientists at NASA’s Jet Propulsion Laboratory are teaming up with European researchers to launch a mission that will probe the oceans’ depths over the next decade — and chart their inexorable rise.

The Sentinel-6/Jason-CS mission builds on four previous satellites that have circled the globe along the same path since 1992, carefully documenting the millimeter-by-millimeter changes in sea level fueled by greenhouse gas emissions. Over that time, they have found that the world’s oceans are rising at an increasingly rapid rate.

The rising waters have had some disastrous consequences, including the erosion of precious coastlines, contamination of agricultural land, more frequent and destructive high tides, and lost habitat for both humans and wildlife.

The Jason satellites, coupled with complementary readings from other NASA Earth-facing missions, have been essential to tracking these changes and dealing with their consequences, said R. Steven Nerem, a professor of aerospace engineering sciences at the University of Colorado Boulder and member of NASA’s Ocean Surface Topography Science Team.

“Without the satellites we’d be blind,” said Nerem, who has tracked sea level rise and its causes for decades. “It’s just very critical that we continue these missions because it’s the way we understand what’s going on.”

Earth’s oceans have swelled and shrunk for eons, but they’ve typically done so very gradually, rather than at the breakneck pace being recorded today.

Recent readings put the rate at roughly 4.5 millimeters per year, up from about 3 millimeters per year in 2005 and around 2 millimeters per year in 1993. Add it all up and the seas are now about 3 inches higher, on average, than they were a quarter-century ago.

The question the new Sentinel-6/Jason-CS mission will seek to answer is this: How much faster will the seas rise in the coming decade? And what will happen to Earth beyond then?

“Hundreds of millions of people around the Earth will be affected by sea level rise in the next 50 to 100 years, and our ability to measure how much of that is human-caused is really rooted in these satellites,” said JPL climate scientist Josh Willis, NASA’s project scientist for Jason-CS.

Since the dawn of the industrial age, humans have been emitting excess amounts of carbon dioxide and other heat-trapping gases, causing Earth’s temperature to rise. Melting glaciers have added water to the oceans. The additional heat also causes water to expand, pushing sea levels up even higher.

Altogether, the oceans have absorbed more than 90% of the extra heat trapped by greenhouse gases, Willis said.

And since they cover more than two-thirds of Earth’s surface, the oceans are reshaping the planet.

“The oceans, in a really big way, are kind of our most important indicator of just how much humans have changed the climate since the start of the industrial revolution,” Willis said.

From an orbit 830 miles above Earth, Sentinel-6/Jason-CS will scan 95% of the planet’s ice-free oceans, gathering a new set of global data every 10 days. Its altimeter will bounce a radar signal off the water’s surface, measuring the time it takes for the signal to return and using that information to calculate the ocean’s height.

Other instruments will hone those readings by compensating for the atmosphere’s effect on the timing of these radar signals, and by helping keep track of the spacecraft’s precise position.

The first Sentinel spacecraft in a clean room in Germany. The satellite is scheduled to launch in November.

(IABG)

Beyond average sea level, the radar readings will provide a wealth of additional information for researchers, who can use them to determine heat changes in the upper ocean, the flow of ocean currents, wave heights and the speed of wind over the water.

The data may even shed light on much of the still-mysterious topography of the sea floor, said Eric Leuliette, the Jason program and project scientist for the National Oceanic and Atmospheric Administration.

“As my colleagues here often point out, we’ve mapped Venus, the moon and Mars better than we’ve mapped the bottom of the ocean,” he said.

Jason data hits the ground running, Leuliette said. Within hours, it’s sent out to National Weather Service forecasters, whose predictions are used by ships for navigation and other maritime purposes. Within a day, it goes into models that help meteorologists make better predictions about large weather events. For example, the information Jason gathers on how much heat is stored beneath the ocean surface can help in forecasting the intensity of a hurricane, or the strength of an El Niño event.

Sentinel-6/Jason-CS is part of an international collaboration involving NASA, NOAA, the European Space Agency, the European Organization for the Exploitation of Meteorological Satellites (EUMETSAT) and France’s National Center for Space Studies (CNES).

The spacecraft will fly in the same orbit as its predecessors, to ensure an unbroken line of sea level readings. That consistency is key for predicting future sea level rise — and preparing for its consequences, Willis said.

Unlike prior missions, which involved only a single spacecraft, this one will employ two satellites, each with a primary mission of five years, said Parag Vaze, Jason’s project manager at JPL. The first is scheduled to launch from Vandenberg Air Force Base in California in November, and the second will follow in 2025, making it the most long-lived of the Jason missions to date.

Sentinel-6/Jason-CS will also meet a different end than its forebears, Vaze said.

In an effort to reduce the accumulation of space junk, the two satellites will be the first in the Jason line to execute a planned de-orbit once they complete their final tasks. Even as the older satellites continue to circle the globe, their younger brethren will burn up in the atmosphere as they plunge back toward Earth.





Source

Continue Reading

Trending

//onvictinitor.com/afu.php?zoneid=2954224
We use cookies to best represent our site. By continuing to use this site, you agree to the use of cookies.
Yes